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what if your blood pressure is fluctuates to hypertensive and non hypertensive

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Meta-Analysis

. 2019 Jun;34(6):547-555.

doi: ten.1007/s10654-019-00510-9. Epub 2022 Mar 22.

Blood pressure, hypertension and the chance of abdominal aortic aneurysms: a systematic review and meta-analysis of cohort studies

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  • PMID: 30903463
  • PMCID: PMC6497813
  • DOI: x.1007/s10654-019-00510-9

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Meta-Analysis

Blood force per unit area, hypertension and the take a chance of abdominal aortic aneurysms: a systematic review and meta-analysis of cohort studies

Elsa Kobeissi  et al. Eur J Epidemiol. 2019 Jun .

Gratuitous PMC article

Abstruse

Intestinal aortic aneurysms (AAA) are fatal in 80% of the cases when ruptured. Hypertension has been considered a potential risk factor for AAA; just the findings from prospective accomplice studies have non been entirely consistent, nor have they been summarised in a comprehensive meta-analysis. Our aim was to comport a systematic review and meta-assay of cohort studies of the association between blood pressure, hypertension and AAA to clarify the force and shape of these associations. We searched PubMed and Embase databases for relevant accomplice studies up to April 30th, 2018. Random-effects models were used to calculate summary relative risks (RRs) and 95% confidence intervals (CIs). The meta-analysis included 21 cohort studies (xx publications) with information on 28,162 cases and five,440,588 participants. The findings indicate that the RR of AAA in hypertensive patients is one.66 times (95% CI: 1.49-i.85, I2 = 79.three%, north = xiii) that of non-hypertensive patients. In addition, there was a 14% (95% CI: 6-23%, Itwo = xxx.5%, northward = 6) and a 28% (95% CI: 12-46%, I2 = 80.1%, n = 6) increase in the RR of AAA for every 20 mmHg and x mmHg increase in systolic blood force per unit area (SBP) and diastolic blood pressure level (DBP), respectively. The analysis of DBP showed testify of a stiff and highly significant nonlinear dose-response relationship (p < 0.001) with a steeper association from 80 mmHg and above. This meta-analysis suggests that hypertension increases the risk of developing AAA past 66%. Further studies are needed to clarify the underlying mechanism explaining the much stronger association betwixt DBP and AAA than for SBP.

Keywords: Abdominal aortic aneurysm; Blood pressure; Accomplice; Hypertension; Meta-assay; Systematic review.

Figures

Fig. 1
Fig. 1

Study menstruum diagram. Made in accordance with PRISMA statement with modifications

Fig. 2
Fig. 2

Hypertension and abdominal aortic aneurysm

Fig. 3
Fig. three

Linear and nonlinear dose–response analyses of SBP, DBP and risk of AAA, a linear dose–response analysis of SBP and risk of AAA, per 20 mmHg, b linear dose–response analysis of DBP and risk of AAA, per ten mmHg, c nonlinear dose–response analysis of SBP and risk of AAA, d nonlinear dose–response analysis of DBP and take a chance of AAA

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